Pacific Northwest National Laboratory Jobs

Job Information

Pacific Northwest National Laboratory Senior Scientist in Native Proteomics in RICHLAND, Washington

Organization and Job ID

Job ID: 310605

Directorate: Earth & Biological Sciences

Division: Biological Sciences

Group: Integrative Omics

Job Description

The world-class Integrative Omics group at Pacific Northwest National Laboratory (PNNL) is seeking a Senior Scientist (similar to Assistant/Associate Professor level) experienced in biochemistry and/or mass spectrometry with distinguished accomplishments in mass-spectrometry-based structure and function characterization of proteins. In particular, native and top-down mass spectrometry experience is desired. The successful candidate will be a multi-disciplinary scientist that can both lead and work in teams of biochemists, mass spectrometrists, computational scientists, and instrument developers to collaboratively transform the technologies and applications related to protein function determination.

With this position, we aim to understand the deep functions of proteins in biological systems. Mass spectrometry is one methodology that has great promise and has been used increasingly to understand the function of proteins. We are seeking a scientist that understands the complex interplay of protein structure, molecular interactions, and mass spectrometry methods to elucidate function, principally using Native Mass Spectrometry methods. Further, the exceptional scientist will be able to lead and collaborate to increase sample and knowledge throughput for protein function including metabolite protein interactions and change of molecular structure through cooperative binding by using mass spectrometry. The Integrative Omics group has extensive mass spectrometry tools and allied capabilities, such as data extraction and processing to support the selected scientist.

This effort includes deep team interactions to aid in guiding the application of new mass spectrometry related technologies and capabilities, including PNNL's Structures for Lossless Ion Manipulation (SLIM) ion mobility platform, to address important scientific questions.

In addition, this senior scientist will be expected to develop new vigorous research programs while helping expand established efforts in native and top-down proteomics and related omics domains by leveraging the highly collaborative research environment of PNNL. This position further requires the ability to convey the breadth and depth of research programs in a variety of venues; thus the candidate must have experience presenting at national and international conferences, in addition to writing scientific publications and grant proposals to demonstrate their ability to develop new methods or identify novel insights from mass spectrometry data. This position may require interaction with government agencies at all stages of project execution and thus a demonstrated skill in presenting to both highly technical and non-technical audiences is desirable. We seek individuals with a strong record of independently directed technical work, but who thrive in a collaborative multi-disciplinary research environment.

The successful candidate will bring senior scientific leadership to PNNL to expand our research programs and leverage the extensive scientific expertise and instrumentation available at PNNL.

The hiring level will be determined based on the education, experience and skill set of the successful candidates based on the following:

Level 3 : Manages small to moderate projects and/or major project tasks. Integrates intellectual and technical capabilities of work teams. Enhances technical/professional skills of junior staff through active mentoring and training. Generates ideas for new proposals and participates in business development activities.

Level 4 : Conceives, plans, and executes R&D with considerable influence on scientific and technological developments. Displays considerable leadership in defining scientific and technical objectives across programs. Leads in the capture, planning, and technical execution of complex interdisciplinary projects and programs across organizational boundaries with lab level impact, and outside of the laboratory.

Required Components of the Application:

In a single PDF file please submit a cover letter describing qualifications and a CV.

Minimum Qualifications

  • BS/BA with 5+ years of experience, MS/MA with 3+ years of experience, or a Ph.D. with 1+ years of experience.

  • Considerable experience in experimental conception, design, execution, and data interpretation.

Preferred Qualifications

  • BS/BA with 7+ years of experience, MS/MA with 5+ years of experience, or a Ph.D. with 3+ years of experience.

  • Strong preference for candidates with PhD in biochemistry, analytical chemistry, molecular biology, synthetic biology, biochemical engineering, or a related field with at least 10 years of experience working in the protein structure-function field.

  • Ideal candidates will have experience in the development and application of mass spectrometry applied to solve biological questions associated with protein function.

  • Skilled professional with a track record of accomplishments in native proteomics.

  • A sustained track record of disseminating research through peer-reviewed publications, invited presentations, etc.

  • Strong communication skills and ability to work both independently as well as in interdisciplinary group settings with internal and external collaborators.

Equal Employment Opportunity

Battelle Memorial Institute (BMI) at Pacific Northwest National Laboratory (PNNL) is an Affirmative Action/Equal Opportunity Employer and supports diversity in the workplace. All employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital or family status, sexual orientation, gender identity, or genetic information. All BMI staff must be able to demonstrate the legal right to work in the United States. BMI is an E-Verify employer. Learn more at

Please be aware that the Department of Energy (DOE) prohibits DOE employees and contractors from participation in certain foreign government talent recruitment programs. If you are offered a position at PNNL and are currently a participant in a foreign government talent recruitment program you will be required to disclose this information before your first day of employment.

Directorate: Earth & Biological Sciences

Job Category: Scientists/Scientific Support

Group: Integrative Omics

Opening Date: 2020-03-03

Closing Date: 2020-05-02