Pacific Northwest National Laboratory Jobs

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Job Information

Pacific Northwest National Laboratory Post Doctorate RA - General Neuroproteomics in RICHLAND, Washington

Organization and Job ID

Job ID: 311267

Directorate: Earth & Biological Sciences

Division: Biological Sciences

Group: Integrative Omics

Job Description

A few post-doctoral positions available in Integrative Omics group at PNNL for collaborative project involving Columbia University, Vanderbilt University and Rush Alzheimer’s Disease Center.

The successful applicants will be immersed into application of proteomics to the research of Alzheimer’s disease (AD) and associated pathologies affecting cognition. There is a number of projects to choose from. One project involves profiling post-translational modifications across human brain samples of subjects with AD and controls. The objective of this project is to refine our understanding of the pathologic mechanism and potentially develop drug targets. Another project focuses on validation of nominated drug targets by large-scale (>1,000 samples) quantitative targeted proteomics (SRM) analysis. The highly quantitative data jointly with rich clinical data enables inference of the role of individual proteins in neurodegeneration by advanced statistical modeling techniques. Third project focuses on small-scale analysis of microglia samples enriched from post-mortem human brains using FACS technique. Finally, forth project aims at development of a method for estimating age and turnover of the beta-amyloid plaques using advanced ion mobility separation technique.

These post-doctoral positions provide opportunities to learn a variety of proteomics techniques, the cutting-edge developments in AD research and statistical analysis of omics and clinical data. The latest research along these directions can be learned from the following publications:

Details about the proteomics group in general can be learned at the web site: PNNL provides a highly collaborative environment with opportunities to satisfy broad scientific curiosity and develop a professional network.

Minimum Qualifications

Candidates must have received a PhD within the past five years (60 months) or within the next 8 months from an accredited college or university.

Preferred Qualifications

Strong organization and communication skills are needed to work efficiently in a team environment and to effectively demonstrate project success.

The successful candidate will have a Ph.D. in one of the disciplines: neurobiology, neurology, biochemistry or bioanalytical chemistry. Solid background in statistics and experience with statistical software is required. R or python programming skills is a plus.

Equal Employment Opportunity

Battelle Memorial Institute (BMI) at Pacific Northwest National Laboratory (PNNL) is an Affirmative Action/Equal Opportunity Employer and supports diversity in the workplace. All employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital or family status, sexual orientation, gender identity, or genetic information. All BMI staff must be able to demonstrate the legal right to work in the United States. BMI is an E-Verify employer. Learn more at

Please be aware that the Department of Energy (DOE) prohibits DOE employees and contractors from participation in certain foreign government talent recruitment programs. If you are offered a position at PNNL and are currently a participant in a foreign government talent recruitment program you will be required to disclose this information before your first day of employment.

Directorate: Earth & Biological Sciences

Job Category: Post-Graduates and Post-Docs

Group: Integrative Omics

Opening Date: 2020-10-07

Closing Date: 2020-11-06